A systematic review of the role of gummosin Gummosis in improving memory in the scopolamine memory impairment model

Document Type : Review Article

Authors

1 Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

2 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

10.32592/ARI.2024.79.2.248

Abstract

This study systematically investigated the role of Gummosin in improving memory in the scopolamine impaired memory model. Memory and learning are the most evolved and complex functions of the nervous system. Learning is the acquisition of new information that occurs as a change in behavior, and memory is the ability to store and retrieve learned information. In other words, memory is a combination of different processes of acquiring, consolidating, storing and recalling information. Memory consolidation and storage processes are the result of a series of time-dependent neurobiological events that occur after the initial formation of memory. In addition, this fluctuation in processes related to memory storage can fully occur shortly after the original learning experience. Memory is a direct result of learning due to storing and retrieving learned experiences and information. The results of our study showed that scopolamine causes impairment of memory, learning and synaptic plasticity, which was associated with changing the expression of various genes and reducing the number of hippocampal neurons. The disorders that occurred in scopolamine group rats confirm the model used in this study to induce memory and learning deficits, which, in line with previous studies, confirms the model used to induce Alzheimer's. The results of the behavioral tests of this study showed that, in accordance with previous works, scopolamine caused a significant increase in anxiety behaviors, which was associated with a decrease in the time spent in the central area compared to the control group, while donepezil injection led to a decrease in anxiety behaviors. It was possible to increase the time spent in the central area compared to the scopolamine group.

Keywords

Archives of Razi Institute
Volume 79, Issue 2
March and April 2024
Pages 248-263

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